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White grapefruit juice and oxycodone12/17/2023 You may report side effects to the FDA at 1-80. Common side effects of oxycodone include constipation, itching, sleepiness, and dizziness. It's available in both immediate-release (IR) and extended-release (ER) forms. If you notice any other effects, check with your healthcare professional.Ĭall your doctor for medical advice about side effects. Oxycodone is an opioid pain medication that's used to help with pain that isn't relieved by non-opioid pain medications. Other side effects not listed may also occur in some patients. Numbness of the feet, hands, and around the mouth Muscle stiffness, tension, tightness, pain, or weakness Loss in sexual ability, desire, drive, or performance Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them: More commonĪbsent, missed, or irregular menstrual periodsĬontinuous ringing or buzzing or other unexplained noise in the earsĭelusions of persecution, mistrust, suspiciousness, or combativenessĮxcess air or gas in the stomach or bowelsįeeling of constant movement of self or surroundings Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. These side effects may go away during treatment as your body adjusts to the medicine. Some side effects may occur that usually do not need medical attention. Irregular, fast, or slow, or shallow breathing Get emergency help immediately if any of the following symptoms of overdose occur: Symptoms of overdoseĬonstricted, pinpoint, or small pupils (black part of the eye)Ĭoughing that sometimes produces a pink frothy sputum Irregular, fast, slow, or shallow breathing Trembling or shaking of the hands or feet Swollen, painful, or tender lymph glands in the neck, armpit, or groin Puffiness or swelling of the eyelids or around the eyes, face, lips, or tongue These studies show that it is not advisable to drink grapefruit juice if you are taking any opioid drugs, including codeine, due to a risk of toxic levels.Check with your doctor immediately if any of the following side effects occur: Less commonĭizziness, faintness, or lightheadedness when getting up suddenly from a lying or sitting positionīloating or swelling of the face, arms, hands, lower legs, or feetīurning while urinating burning, crawling, itching, numbness, prickling, "pins and needles", or tingling feelingsįast, irregular, pounding, or racing heartbeat or pulseįlushing or redness of the skin, especially on the face and neck It found that grapefruit increases the bioavailability of methadone in a patient and could result in a toxic level. A 2004 study published in “Clinical Pharmacology and Therapeutics” looked at the effects of grapefruit juice on CYP3A4 in patients taking methadone 3 4. The study showed that drinking grapefruit juice or eating a grapefruit can increase the concentrations of the drug in the body. A 2010 study published in “Basic and Clinical Pharmacology and Toxicology” looked at the effects of grapefruit juice and another opiate, oxycodone 3 4. Codeine, according to the National Institutes of Health, is used to treat mild to moderate pain as well as in some medications to treat coughing.Ĭonsuming grapefruit juice while taking codeine is not advised due to the furanocumarins found in the grapefruit.Codeine is in the class of drugs called opiates, which includes drugs like morphine, hydrocodone, methadone and oxycodone.Although we strive to deliver accurate and up-to-date information, no guarantee to that effect is made. Please check with the appropriate physician regarding health questions and concerns. The information contained on this site is for informational purposes only, and should not be used as a substitute for the advice of a professional health care provider. “Clinical Pharmacology and Therapeutics” Effects of Grapefruit Juice on the Pharmacokinetics of the Enantiomers of Methadone M.“Basic and Clinical Pharmacology and Toxicology” Grapefruit Juice Enhances the Exposure to Oral Oxycodone TH Nieminen et al.The Harvard Medical School Family Health Guide Grapefruit and Medication: A Cautionary Note February 2006.The sources cited below consist of evidence from peer-reviewed journals, prominent medical organizations, academic associations, and government data. Our team periodically reviews articles in order to ensure content quality. At Healthfully, we strive to deliver objective content that is accurate and up-to-date.
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